Fentanyl
Lumiracoxib
Lercanidipin
Nilvadipine
Valganciclovi
Gemfibrozil
Levofloxacin
Topotecan
Amprenavir
Zileuton
Diclofenac
Cabergoline
Vancomycin
Anagrelide
Fludarabine
Lacidipine
Gatifloxacin
Saquinavir
Troglitazone
Voriconazole
Irbesartan
Indinavir
Glimepiride
Zaprinast
Duloxetine
Irinotecan
Amosulalol
Etoricoxib
Mevastatin
Flupentixol
Zonisamide
Anastrozole
Ceftiofur
Sotalol
Rosiglitazone
Isotretinoin
Tolterodine
Oxaliplatin
Vinorelbine
Paclitaxel
Flurocitabine
Enocitabine
Decitabine
Fluorouracil
Calcium Levofolinate
Tegafur
Triptorelin
Relenza
Colchicine
Amifostine
Salcalcitonin
Homoharringtonine
Fluvoxamine Maleate
Venlafaxine
Tarceva
Tamoxifen
Nelarabine
Clobetasol
Atorvastatin
Pioglitazone
Tramadol
Valsartan
Ramelteon
Topiramate
Pregabalin
Metformin Hhydrochloride
Meropenem
Ciprofloxacin

Pimecrolimus

For Souring from China, Please Contact Us

(CAS: )

Recommend Site:

Chemical Name: (1R,9S,12S,13R,14S,17R,18E,21S,23S,24R,25S,27R)-12-[(1E)-2-{(1R,3R,4S)-4-chloro-3-methoxycyclohexyl}-1-methylvinyl]-17-ethyl-1,14-dihydroxy-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-aza-tricyclo[22.3.1.04,9]octacos-18-ene-2,3,10,16-tetraone.

Trade Name: Elidel? (Novartis)

Molecular Formula: C43H68CINO11

MolecularWeight: 810.47

Sturcture of Pimecrolimus:

Pimecrolimus is a white to off-white fine crystalline powder. It is soluble in methanol and ethanol and insoluble in water.

What is the most important information I should know about pimecrolimus topical?

# The FDA has issued a public health advisory to inform healthcare providers and patients about a potential cancer risk from use of pimecrolimus when applied to the skin. This concern is based on information from animal studies, case reports in a small number of patients, and how these drugs work. It may take human studies of ten years or longer to determine if use of pimecrolimus is linked to cancer. In the meantime, this risk is uncertain and FDA advises that pimecrolimus should be used only as labeled, for patients who have failed treatment with other therapies.
# Avoid sunlight and sun lamps, tanning beds, and treatments with UVA or UVB light. If you need to be outdoors after applying pimecrolimus topical, wear loose clothing that protects the treated area from the sun. Also, ask your doctor what other type of protection from the sun may be needed.
# Even though your skin will begin to look and feel better, it is important to keep using pimecrolimus topical as instructed by your doctor. Pimecrolimus topical should be used for as long as the symptoms of atopic dermatitis persist or as directed by your doctor.
# Talk to your doctor if the condition does not improve or if it gets worse during the first few weeks of treatment.
# Unless otherwise instructed by your doctor, do not apply any other skin products on the areas treated with pimecrolimus topical.

What is pimecrolimus topical?

# Pimecrolimus is an immunosuppressant. Immunosuppressants decrease the effects of the body's immune system.
# Pimecrolimus topical is used to treat atopic dermatitis (e.g., eczema).
# Pimecrolimus topical may also be used for purposes other than those listed in this medication guide.

What should I discuss with my healthcare provider before using pimecrolimus topical?

# The FDA has issued a public health advisory to inform healthcare providers and patients about a potential cancer risk from use of pimecrolimus when applied to the skin. This concern is based on information from animal studies, case reports in a small number of patients, and how these drugs work. It may take human studies of ten years or longer to determine if use of pimecrolimus is linked to cancer. In the meantime, this risk is uncertain and FDA advises that pimecrolimus should be used only as labeled, for patients who have failed treatment with other therapies.
# Do not use pimecrolimus topical without first talking to your doctor if you have the congenital skin disorder Netherton's syndrome.
# Before using pimecrolimus topical, tell your doctor if you:
, are taking oral or injectable tacrolimus (Prograf), cyclosporine (Neoral, Sandimmune), mycophenolate mofetil (CellCept), azathioprine (Imuran), sirolimus (Rapamune), or another immunosuppressant medication;
, have a skin infection;
, have a disease of the immune system; or
, are using any other type of skin product (e.g., cream, ointment, lotion, etc.).
# You may not be able to use pimecrolimus topical, or you may require a dosage adjustment or special monitoring if you have any of the conditions listed above.
# Pimecrolimus topical is in the FDA pregnancy category C. This means that it is not known whether pimecrolimus topical will harm an unborn baby. Do not use this medication without first talking to your doctor if you are pregnant or are planning to become pregnant during treatment.
# It is not known whether pimecrolimus passes into breast milk. Do not use this medication without first talking to your doctor if you are breast-feeding a baby.
# Pimecrolimus topical is not approved for use by children younger than 2 years of age.

How should I use pimecrolimus topical?

# Apply pimecrolimus topical exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse or doctor to explain them to you.
# Apply pimecrolimus topical twice a day, about 12 hours apart, unless otherwise directed by your doctor.
# Wash your hands before and after each application, unless you are using pimecrolimus topical to treat a hand condition.
# Before applying pimecrolimus topical after a shower or bath, be sure the skin is completely dry.
# Apply a thin layer of pimecrolimus topical to all skin areas that your doctor has diagnosed as having atopic dermatitis (e.g., eczema). Rub the medication gently and completely into the skin.
# Do not cover the area being treated with bandages, dressings, or wraps. However, normal clothing can be worn over the treated areas.
# Unless otherwise instructed by your doctor, do not apply any other skin products on the areas treated with pimecrolimus topical.
# Do not bathe, shower or swim right after applying pimecrolimus topical. This could wash off the medication.
# Use pimecrolimus topical on the skin. Do not swallow this medication.
# Even though your skin will begin to look and feel better, it is important to keep using pimecrolimus topical as instructed by your doctor. Pimecrolimus topical should be used for as long as the symptoms of atopic dermatitis persist or as directed by your doctor.
# Talk to your doctor if the condition does not improve or if it gets worse during the first few weeks of treatment.
# Store pimecrolimus topical at room temperature away from moisture and heat.

What happens if I miss a dose?

# Use the missed dose as soon as you remember. If it is almost time for the next dose, skip the dose you missed, and use only the next regularly scheduled dose.

What happens if I overdose?

# If pimecrolimus topical is ingested, seek emergency medical attention.
# Symptoms of a pimecrolimus topical overdose are not known.

What should I avoid while using pimecrolimus topical?

# Avoid sunlight and sun lamps, tanning beds, and treatments with UVA or UVB light. If you need to be outdoors after applying pimecrolimus topical, wear loose clothing that protects the treated area from the sun. Also, ask your doctor what other type of protection from the sun may be needed.
# Do not cover the area being treated with bandages, dressings, or wraps. However, normal clothing can be worn over the treated areas.

What are the possible side effects of pimecrolimus topical?

# If you experience an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives), stop using pimecrolimus topical and seek emergency medical attention.
# It is not unusual to experience skin burning, stinging, itching, or soreness at the site of application of the medication. These side effects are most common during the first few days of treatment and typically improve as the lesions of atopic dermatitis heal.
# Other, less serious side effects may be more likely to occur. Continue to use pimecrolimus topical and talk to your doctor if you experience:
, irritation of nose and throat;
, cough;
, headache;
, diarrhea, constipation, or upset stomach; or
, skin infection.
# Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect pimecrolimus topical?

# Unless otherwise instructed by your doctor, do not apply any other skin products on the areas treated with pimecrolimus topical.
# Talk to your doctor before taking another medicine that may affect the immune system such as oral or injectable tacrolimus (Prograf), cyclosporine (Neoral, Sandimmune), mycophenolate mofetil (CellCept), azathioprine (Imuran), sirolimus (Rapamune), or another immunosuppressant medication. You may not be able to use pimecrolimus topical, or you may require a dosage adjustment or special monitoring if you are taking another medicine that affects the immune system.
# Although unlikely, other systemic medications (taken by mouth or injection) may interact with pimecrolimus topical. Talk to your doctor before taking any of the following medicines during treatment with pimecrolimus topical:
, an antifungal medicine such as ketoconazole (Nizoral), itraconazole (Sporanox), or fluconazole (Diflucan);
, a calcium channel blocker (heart medicine) such as verapamil (Calan, Verelan), diltiazem (Cardizem, Dilacor XR, Tiazac), nifedipine (Adalat, Procardia), or nicardipine (Cardene);
, erythromycin (Ery-Tab, E-Mycin, E.E.S., others), clarithromycin (Biaxin), or troleandomycin (TAO); or
, cimetidine (Tagamet, Tagamet HB).
# Drugs other than those listed here may also interact with pimecrolimus topical. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines, including herbal products.

What is the recommend dosage of pimecrolimus?

Apply a thin layer of Elidel? (pimecrolimus) Cream 1% to the affected skin twice daily and rub in gently and completely. Elidel? may be used on all skin surfaces, including the head, neck, and intertriginous areas.

Elidel? should be used twice daily for as long as signs and symptoms persist. Treatment should be discontinued if resolution of disease occurs. If symptoms persist beyond 6 weeks, the patient should be re-evaluated.

The safety of Elidel? Cream under occlusion, which may promote systemic exposure, has not been evaluated. Elidel? Cream should not be used with occlusive dressings.

 

Where can I get more information?

# Your pharmacist has additional information about pimecrolimus topical written for health professionals that you may read.