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Methotrexate

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(CAS: 133073-73-1)

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CAS: 133073-73-1

Chemical Name: N -[4-[[(2,4-diamino-6-pteridinyl)methyl]methyl-amino]benzoyl]-L-glutamic acid

Structure:

What happens if I miss a dose?
? Contact your doctor if you miss a dose of methotrexate.

What happens if I overdose?
? Seek emergency medical attention if an overdose is suspected.
? Symptoms of a methotrexate overdose may include nausea, vomiting, bleeding in the stomach, sores in the mouth, blood and bone marrow problems, and possibly death.

What should I avoid while taking methotrexate?
? Do not take aspirin or nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen (Advil, Motrin, Nuprin, others), ketoprofen (Orudis KT, Orudis, Oruvail), naproxen (Aleve, Naprosyn, Anaprox), and others except under the direction of your doctor. Although these medications may be prescribed together to treat certain conditions, methotrexate may interact with aspirin and NSAIDs, and possibly cause serious side effects. Discuss the use of aspirin and NSAIDs with your doctor.
? Do not drink alcohol while taking methotrexate.
? Avoid prolonged exposure to sunlight. Methotrexate may increase the sensitivity of the skin to sunlight. Use a sunscreen and wear protective clothing when exposure to the sun is unavoidable.

What are the possible side effects of methotrexate?
? Methotrexate may cause side effects that could be dangerous or life-threatening. Discuss with your doctor the risks and benefits of using methotrexate before starting treatment. Methotrexate has been reported to cause blood and bone marrow problems (fever, chills, sore throat, unusual bruising or bleeding, black, bloody or tarry stools,); lung problems (unexplained shortness of breath, coughing, or wheezing); stomach problems (diarrhea, abdominal pain); sores in or around the mouth; liver problems (yellow skin or eyes, unusual fatigue); kidney problems (blood in the urine; darkened urine, swelling of the feet or legs); and others. Notify your doctor immediately if you develop any of these symptoms.
? If you experience any of the following serious side effects, seek emergency medical attention or contact your doctor immediately:
, an allergic reaction (shortness of breath; closing of the throat; difficulty breathing; swelling of the lips, face, or tongue; or hives);
, joint pain; or
, confusion, unusual behavior, or seizures.
? Other, less serious side effects may be more likely to occur. Continue to take methotrexate and notify your doctor if you experience
, nausea, vomiting, or decreased appetite;
, itching or a skin rash;
, hair loss;
, boils or acne;
, dizziness;
, increased sensitivity of the skin to sunlight;
, headache;
, drowsiness; or
, blurred vision.
? Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect methotrexate?
? Do not take aspirin or nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen (Advil, Motrin, Nuprin, others), ketoprofen (Orudis KT, Orudis, Oruvail), naproxen (Aleve, Naprosyn, Anaprox), and others except under the direction of your doctor. Although these medications may be prescribed together to treat certain conditions, methotrexate may interact with aspirin and NSAIDs, and possibly cause serious side effects.
? Before taking methotrexate, tell your doctor if you are taking any of the following medicines:
, etretinate (Tegison);
, acitretin (Soriatane);
, theophylline (Theo-Dur, Theolair, Theochron, Elixophyllin, Slo-Phyllin, others);
, phenytoin (Dilantin);
, probenecid (Benemid);
, procarbazine (Matulane);
, a penicillin antibiotic such as ampicillin (Principen, others), amoxicillin (Amoxil, Trimox, Augmentin, others), dicloxacillin (Dynapen, others), penicillin (Pen-Vee-K, Veetids, others), and others;
, a tetracycline antibiotic such as minocycline (Minocin, Dynacin, others), doxycycline (Vibramycin, Vibra-Tabs, others), tetracycline (Sumycin, others), and others; or
, a sulfa-based medicine such as sulfamethoxazole (Bactrim, Septra, Sulfatrim, Gantanol), sulfisoxazole (Gantrisin), and others.
? You may not be able to take methotrexate, or you may require a dosage adjustment or special monitoring if you are taking any of the medicines listed above.
? Drugs other than those listed here may also interact with methotrexate. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines, including vitamins, minerals, and herbal products.