Home	Carbohydrate	Amino Acid	Peptide	Chiral Compound
Water Treatment	Generic Pharmaceutical	Detergent Chemical	Agrochemical	Dyement and Pigment
Basic Chemicals	Plant Extract	Steroids	Vitamin	Biopharmaceutical
Surfactant	Food Ingredient	Essence and Flavor	Pharmaceutical Intermediate

Ascorbyl palmitate

(CAS#: 137-66-6)

Recommedn Site:

Synonyms: Ascorbyl palmitate; 6-O-Palmitoylascorbic acid; L-Ascorbic acid, 6-hexadecanoate; L-Ascorbic acid, 6-palmitate

Ascorbyl palmitate is a fat-soluble form of ascorbic acid, or vitamin C. Unlike ascorbic acid, which is water-soluble, ascorbyl palmitate is not water-soluable. Consequently ascorbyl palminate can be stored in cell membranes until it is required by the body. Many people think vitamin C (ascorbyl palminate) is only used for immune support, but it has many other important functions. A major role of vitamin C is in manufacturing collagen, a protein that forms the basis of connective tissue - the most abundant tissue in the body. Ascorbyl palmitate is an effective free radical-scavenging antioxidant which promotes skin health and vitality.

ASCORBYL PALMITATE

• What is Ascorbyl Palmitate? Ascorbyl Palmitate is a lipid (fat) soluble form of vitamin C. Ascorbyl Palmitate maintains all the physiologic activity of vitamin C without the problems that can be associated with ascorbic acid (the common water soluble form of vitamin C).

• Ascorbyl Palmitate turns on cellular machinery. Human cell cultures designed to closely simulate the human body, demonstrate this effect. By enhancing the cells ability to function more effectively, cells are better able to repair any damage and generally “act” in a younger manner.

• Ascorbyl Palmitate is a neutral pH (non-acidic) molecule. C-ESTA can be applied to any skin type without irritation as opposed to Ascorbic Acid whose extremely low acidic pH can create inflammation. C-ESTA does not sting or burn. C-ESTA can be used with glycolic acid, Retin-A? and after laser resurfacing to assist in the recovery process.

• Because Ascorbyl Palmitate is fat soluble, it penetrates the skin very rapidly and intersperses in the cell membrane. This affinity with the cell membrane results in tremendous antioxidant benefits and helps to prevent cellular aging such as:
  
  
  • Cross linking of collagen
  • Oxidation of proteins
  • Lipid peroxidation
    
    
• Ascorbyl Palmitate acts as an anti-inflammatory. The molecule was tested on several human inflammatory models. Studies demonstrated anti-inflammatory activity when Ascorbyl Palmitate is applied to psoriasis. Studies also show that Ascorbyl Palmitate can dramatically decrease UVB induced erythema (sunburn) when applied topically.

• Ascorbyl Palmitate is more active than Ascorbic Acid. A study conducted at the University of North Carolina compared the efficacy of Ascorbic Acid and Ascorbyl Palmitate in the suppression of phorbol ester induced tumor production (tumors nearly identical to those caused by UV light exposure). This study demonstrated that, while Ascorbyl Palmitate and Ascorbic Acid both have tumor suppressing activity, Ascorbyl Palmitate was 30 times more effective than Ascorbic Acid at 1/4 the dose.

• Ascorbyl Palmitate is extremely stable. Ascorbyl Palmitate is the only vitamin C molecule that will maintain its vitamin C activity for long periods of time. C-ESTA products have a normal two-year shelf life.

• Ascorbyl Palmitate enhances vitamin E activity in the skin. Because Ascorbyl Palmitate can reside in the cell membrane, it can regenerate the vitamin E radical on a continuous basis. This is as opposed to Ascorbic Acid, which only interacts with vitamin E at the interface of the water-soluble and lipid components.

• Ascorbyl Palmitate has been proven to be physiologically active in human cell cultures.
  
  
  • Ascorbyl Palmitate shows greater activity than Ascorbic Acid in fibroblast growth and collagen production.
  • Ascorbyl Palmitate shows greater activity than Ascorbic Acid at lower doses.
    
    
• Ascorbyl Palmitate has better skin absorption and retention than Ascorbic Acid. In a study conducted by a division of Proctor and Gamble, skin absorption was compared between Ascorbyl Palmitate and Ascorbic Acid. At two hours, skin absorption of Ascorbyl Palmitate was far greater than Ascorbic Acid. At twenty-four hours, the amount of Ascorbyl Palmitate was over nine times greater.

Chemical Safety & Handling:

Disposal Methods:

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

Chemical/Physical Properties:

Molecular Formula: C22H38O7

Molecular Weight: 414.54

Color/Form: White or yellowish white powder

Melting Point: 116℃

Solubilities: Soluble in alcohol, animal oil, & vegetable oil; Silight soluble in water